Our hosts had put together a very inspiring programme with a focus on the work from younger principal investigators. We had oral presentations, poster presentations and, most importantly, we had lots of discussions. The focus of the meeting was on lung inflammation in a range of different lung diseases that include pulmonary fibrosis, chronic obstructive pulmonary disease (COPD) and asthma. Projects included both pre-clinical and clinical approaches in the young and the elderly.
The association of NHLI with Weill-Cornell is an exciting opportunity and there is already a sense that collaborations and joint projects will follow from these initial meetings.
There was a surprising amount of synergy between the research programmes of the two institutions, both at the junior and the senior PI level. Over the two days we covered a large variety of topics such as infection, stem cells, microbiome, tissue repair, remodelling and fibrosis. Our hosts had arranged our visit in the best way possible and treated us with great hospitality – making the time to show us some of the different labs across the campus, setting aside opportunities for collaboration discussions and hosting a very nice dinner party.
Personally, the opportunity to attend this meeting not only gave me the chance to get to know my own colleagues at NHLI better, but also to foster links with our colleagues at Weill Cornell. We look forward to the continuation of these joint meetings and further scientific interactions with our Weill Cornell colleagues.
Department of Cardiovascular Medicine
National Heart and Lung Institute
Imperial College London, UK
The focus of the group is to understand the basic mechanisms which regulate endothelial homeostasis. Endothelial cells regulate critical vascular functions, such as traffic of cells from blood to tissues, clotting, permeability and angiogenesis. Maintenance of endothelial homeostasis is essential for the prevention and control of vascular inflammatory diseases, thrombosis and atherosclerosis. Endothelial cells are also essential to maintain tissue homeostasis, making this area critical for a wide number of diseases and for regenerative medicine approaches.
The laboratory investigates the molecular pathways that regulate endothelial homeostasis, angiogenesis and vascular stability, with a view to identifying novel target and approaches for the prevention and treatment of diseases. Projects in the group focus on three main areas:
1. Transcriptional and epigenetic control of endothelial homeostasis and angiogenesis by the ETS transcription factor ERG
2. von Willebrand Factor regulation of angiogenesis
3. Circulating endothelial progenitors (Blood Outgrowth Endothelial Cells) in regenerative and precision medicine
Dr. Graeme Birdsey, Lecturer and PI
Dr. Claudio Raimondi, BHF Research Fellow
Dr. Neil Dufton, Postdoctoral Fellow
Dr. Claire Peghaire, Postdoctoral Fellow
Dr. Koval Smith, Postdoctoral Fellow
Dr. Koralia Paschalaki, Clinical Fellow
Ms Viktoria Kalna, Graduate (PhD) Student
Ms Josefin Jansson Edqvist, Graduate (PhD) Student
Ms Oisin King, Graduate (PhD) Student
Ms Linda Inuabasi, Research Assistant
Dufton NP, Peghaire CR, Osuna-Almagro L, Raimondi C, Kalna V, Chuahan A, Webb G, Yang Y, Birdsey GM, Lalor P, Mason JC, Adams D and Randi AM. Dynamic regulation of canonical TGFβ signaling by endothelial transcription factor ERG protects from liver fibrogenesis Nat Commun. 2017 in press
K E Paschalaki, A Zampetaki, J R Baker, M A Birrell, R D. Starke, M G Belvisi, L Donnelly, M Mayr, A M Randi*, P J Barnes*. Downregulation of microRNA-126 augments DNA damage response in cigarette smokers and COPD patients. AJRCMM, 2017 in press
Shah AV, Birdsey GM, Peghaire C, Pitulescu ME, Dufton NP, Yang Y, Weinberg I, Osuna Almagro L, Payne L, Mason JC, Gerhardt H, Adams RH, Randi AM. The endothelial transcription factor ERG mediates Angiopoietin-1-dependent control of Notch signalling and vascular stability. Nat Commun. 2017 Jul 11;8:16002.
Randi AM. and Laffan MA. von Willebrand factor and angiogenesis: basic and applied issues. J Thromb Haemost. 2017 Jan;15(1):13-20
Shah AV, Birdsey GM and Randi AM Regulation of endothelial homeostasis, vascular development and angiogenesis by the transcription factor ERG Vascular Pharmacology, 2016 Nov;86:3-13
Birdsey GM, Shah A V, Reynolds LE, Dufton N, Osuna Almagro L, Yang Y, Aspalter IM, Khan ST, Mason JC, Dejana E, Göttgens B, Hodivala-Dilke K, Gerhardt H, Adams RH, and Randi AM. The endothelial transcription factor ERG promotes vascular stability and growth through Wnt/-catenin signalling. Developmental cell 2015; 32(1):82-96
Starke R, Paschalaki K, Dyer C, Harrison-Lavoie K, Cutler J, McKinnon T, Millar C, Cutler D, Laffan M, Randi AM. Cellular and molecular basis of Von Willebrand Disease: studies on blood outgrowth endothelial cells. Blood;121:2773-84; 2013
Ralf Adams (Munster University, Germany)
Shahin Rafii (Cornell, USA)
Michael Simons (Yale, USA)
David Adams (Birmingham, UK)
Michael Laffan (London, UK)
Justin Mason (London, UK)
Elisabetta Dejana (Uppsala, Sweden; Milan, Italy)
9th International BIC meeting, Rome, Italy – September 2017
Angiogenesis Gordon Research Conference (GRC), Salve Regina, RI, USA – August 2017
International Society on Thrombosis and Haemostasis (ISTH) Meeting, Berlin, Germany – July 2017
2nd Joint European Microcirculation Society – European Vascular Biology (EVBO) meeting, Geneva, Switzerland – May 2017
Vulnerable Plaque Meeting, Crete, Greece – May 2017
Society of Thrombosis and Hemostasis Research (Plenary Lecture), Basel, February 2017
The BALR Summer Meeting 2017 took place on 30 August – 1 September in Belfast, where the new committee members were announced in the Annual General Meeting. Amongst the new roles, I was nominated to be the PhD Student Representative of the BALR 2017-19. As such, I want to introduce myself to the NHLI community and encourage students, particularly in the respiratory field, to take advantage of what the BALR and I have to offer.
The BALR seeks to promote respiratory research throughout the UK and therefore provides a platform for all respiratory researchers to exchange ideas, form collaborations and further their pulmonary research. Another aim of the BALR is to offer support to early career researchers and this year’s Summer Meeting is a prime example of how they achieve this; there was an oral competition for both PhD students and early career researchers, giving them an opportunity to nurture their presentation skills.
As PhD Student Representative, my responsibilities include voicing the needs of the student members in the society as well as assisting them in concerns raised to me, from questions about abstracts to what they should wear to meetings. I will also disseminate information about opportunities and news relevant to the PhD student members.
I’m very excited to take on this new role and would encourage all current student members to get in touch with me should they like or need to. I’d also recommend non-members to join the society; amongst the benefits are discounted membership to the European Respiratory Society (ERS) and discounted registration fees to the British Thoracic Society (BTS) Winter Meetings. I continue to profit from being a member of the BALR and hope other students can gain from it as I have. Please see the BALR website for more information.
On 12th – 14th July 2017 the Eighth NIHR Infrastructure Doctoral Research Training Camp titled The Art of Communication was held at Weetwood Hall Conference centre in Leeds. The Imperial Clinical Academic Training Office had been invited to nominate 3 doctoral students for consideration for a place at the camp. I was pleased to be chosen as one of the 3 successfully nominated candidates.
100 delegates from centres across the UK attended. This was the 8th training Camp offering delegate’s access to workshops, inspirational speakers and the practical experience of communicating with a challenging panel of ‘experts’. The specific aim was to equip delegates with the skills and ability to successfully defend and communicate their research effectively with a range of people including fellow scientists, research funders, the media, patients and the public.
There was a dedicated poster session held during the afternoon of 12 July at which I presented my doctoral work on Patient Reported Outcomes. Plenary sessions included a presentation by Dr Giles Yeo Director of Genomics & Transcriptomics, Institute of Metabolic Science University of Cambridge, publically known for his appearance on the BBC2’s Horizon programme Clean Eating – The Dirty Truth.
Dr Yeo gave an amusing and engaging presentation of his experiences of working with journalists and the media. In one encounter his eloquent scientific explanation of obesity was distilled on his behalf to ‘fat is bad’.
The importance of the message was reinforced by Professor Anthony Redmond Professor of Clinical Biomechanics University of Leeds. Delegates were challenged to be able to describe their research in 20 words and themselves in 10 seconds.
Professor Anne-Maree Keenan, Chair of Applied Health Research and Assistant Director and Training Lead, NIHR Leeds Musculoskeletal Biomedical Unit University of Leeds, introduced the delegates to the NIHR Making People Healthier Research Programme. Delegates then worked in 10 small groups supported by a designated mentor with a brief to develop a communications plan for our research. Each group was assigned a published paper to adopt as their research which had been funded by the NIHR Making People Healthier stream.
Two days were spent working with colleagues from Collaboration for Leadership in Applied Health Research and Care (CLAHRCs), Biomedical Research Centres (BRC’s) and Public Health Research units from across the UK we developed a communication plan and presentation for the B-type natriuretic peptide for incident atrial fibrillation – The Heinz Nixdorf Recall study, published in Journal of Cardiology. Mentored by Dr James Frith from University of Newcastle we also had access to workshops on top tips for media interviews using media effectively and PPI in communications we also had 1:1 appointments with the press officer; PPI advisors the NIHR Director and NIHR comms team. There were a few surprises in and amongst such as being hauled out of a media interview with the unrelenting Professor Waljit S Dhillo.
The final morning required all groups to pitch their comms proposal to six members of a Dragon’s den type panel. Professor Dave Jones Dean of NIHR Faculty Trainees and Professor Waljit Dhillo in particular had sharpened their critical appraisal skills and wit in readiness. They were met with well-prepared teams skilled in rebuttal.
Sadly we were not the winning team but it was an excellent learning experience shared with some wonderful colleagues in a supportive NIHR family environment! I advise all NIHR / NHLI doctoral students to get ready for the ninth NIHR training camp next year.
by Anne-Marie Russell @anmari_russell NIHR Clinical Research Fellow Respiratory Epidemiology Occupational Medicine and Public Health
After months of preparation, the President’s Scholars Committee launched the 2017 Research Symposium, which was a great success with over a hundred attendees and really positive feedback from the event. Everyone seemed to enjoy this day in which students interacted and shared visions, practised for their next national/international conference – both presenting and chairing the sessions – learned from their peers and very distinguished Imperial College London Professors, and had a good time networking with other postgraduate students.
The event began with the inspirational talk by Professor Simone Buitendijk, Imperial’s Vice Provost for Education. Many female young researchers were looking forward to hearing her speech. She is a member of the League of European Research Universities Gender Steering Group (LERU); she has a long-lasting interest in gender equality in academia. She not only gave a sensational talk but also showed genuine interest in meeting the committee and making sure she provided absolutely everything that could have been expected for the day.
The Natural Sciences talks were introduced by Professor Fay Dowker, who captivated the audience providing a smart simple physics explanation of time. She also opened the debate on the fact that unexpected results, which may seem not to fit with previous knowledge, can, in fact, lead to groundbreaking results; such as the measure of the acceleration of the universe’s expansion, which lead to a Nobel Prize. She set the bar high, but students Simon Schoeller and Michael Sachs managed to keep the wheels spinning until the coffee break time.
Having had interesting discussions over a coffee, we welcomed the Engineering keynote speaker Professor Nick Jennings. He showed how artificial intelligence (AI) aims to help our society – such as optimising resources in a catastrophe – instead of taking over humankind. Some algorithms have indeed demonstrated they can beat human abilities, although they are only able to respond to very specific commands. This talk was followed by lots of questions from the audience, demonstrating the large interest in AI around Imperial. Students Thibaud Humair, Sana Waheed, Konrad Leibrandt maintained the level when presenting their research afterwards.
Dr Lucia Li was absolutely remarkable as Medicine keynote speaker. She not only showed us how to make magic but also to keep our heads up, and safe. She highlighted the challenges of the acute and long-term management of post-traumatic brain injuries in young people. She is an incredible active doctor and researcher, hugely committed and so lovely to engage with. We all enjoyed her talk, which was noted by the numerous questions she received both during and after her presentation. Once again, postgraduate students – Leor Roseman, Midhat Salman, and Silvia Sposini – did not let the audience down presenting their hard-work.
The event was closed with the thanks from the President’s Students Committee, who had organised the event – Niall Bourke, Maria Anna Chatzopoulou, Amit K. Dwivedi, Terrence Lai, Helena Lund-Palau, Anya Ramgulam, Midhat Salman, Abellona U – gifts for the speakers and poster presenters, and a nice group picture.
On the 26th of May Professor Thomas Brand, Head of the Developmental Dynamics group participated in a science outreach activity, which was organised by the Native Scientist Organisation and the Goethe Institute in London. Two classes with pupils aged 15-16, who had German as second language for at least three years participated in this activity. Four scientists including Prof. Brand gave 15 minutes lectures on their scientific subject.
The lecture by Prof. Brand dealt with the ability of the heart to adapt to stress. He explained what the heart looks like, where the pacemaker is localised in the heart and how an electrocardiogram tells about how the heart functions.
Experiment. Heart rate measurement before and after a brief exercise.
In order to illustrate the ability of the heart to increase its rate of beating, each of the students had to measure their heart rate (pulse) before and after 10 knee bends.
Students do knee bends
Surprisingly we found there was a wide spread of student heart rates – which varied from 36 beats per minute (bpm) to 90 bpm. After the brief training heart rates in most cases went up by around 20-40 bpm.
In two cases however the heart rate was slower than before training, which maybe related to the fact that sitting in front of a real professor may make the heart beat faster and the physical activity was actually relaxing.
The brief lecture ended with some information on the actual research of Prof. Brand who discovered a family of proteins called the Popeye domain proteins, which are involved in the fight or flight response. Mice, zebrafish and also patients carrying mutations in these genes display abnormal heart rates in response to physical stress.
On the 30th and 31st January 2017 the inaugural Health Protection Research Unit (HPRU) PhD Academy was held at the University of Liverpool in London. The National Institute for Health Research created the HPRUs with a view for collaborative research between universities and Public Health England (PHE). The event aimed to stimulate discussion and collaboration across the HPRUs, which include priority areas ranging from blood-borne and sexually transmitted diseases, to the health impact of environmental hazards.
“We think it’s very important to understand where your research fits into the wider picture and world around you and what patients and the public actually think is important”
Held over two days, the academy consisted of oral presentations by students introducing their HPRUs and individual projects. In addition delegates from each HPRU were invited to present posters and discuss their ongoing research.
On the first day guest speakers from Public Health England (PHE) covered topics including the importance of the students’ contribution to PHE and developing a career in public health, as well as conducting an outbreak workshop. Topics covered by the PhD students included evaluating the burden of antimicrobial resistance, a review of Salmonella and determining patient outcome following acute Ebola virus infection.
Each unit was asked to give a brief introduction to their HPRU and the students involved, before two presentations on work within that HPRU. The presentations were kicked off by the HPRU in Health Impact of Environmental Hazards. As a student with this HPRU, I (Kirsty Meldrum) was joined by Alex Cooper (PHE) to give an introduction to our work. Within this unit we are looking at the hazards particles and chemicals may have on the population through the use of wet lab and in silico modelling methods.
The next unit to present was the HPRU in Emergency Preparedness and Response. These presentations were really interesting as they discussed vaccinations and the reasons behind why the uptake of them might be poor. They also presented interesting work on the side effects of medications that might prevent people taking them, and the “nocebo” effect where volunteers are given a placebo and still experience these side effects.
Third to present was the HPRU in Environmental Change and Health who discussed the potential for tick-borne diseases in urban green spaces. The government currently wants to increase ‘green spaces’ yet the potential for these diseases to increase is something that hasn’t been investigated.
“Overall the two days were informal, but very informative – definitely something that would be brilliant to repeat in the future”
The final talk was from the HPRU in Evaluation of Interventions who initially talked about the implication on changing vaccination policy on BCG vaccination, and then went onto to discuss looking at Meningitis B vaccine development at different phases and densities of colonisation.
After a short break there were then further invited speakers that talked about ethics, research integrity and governance (a valuable talk on what is actually required for a clinical trial and the various avenues that could be used to start one) and a talk about getting patients and public involved in research. This talk used personal examples to demonstrate why getting patients and public involved was important and how to go about doing it. Both these speakers were very informative and opened our eyes to the larger world of research, not just being in the lab!
On the 18th March members of the Muscle Lab (Dr Matt Pavitt, Dr Karthi Srikanthan and Dr Ahmad Sadaka) ran a stand at the Imperial Fringe: Sports and Science Day in White City in association with Queens Park Rangers FC. The stall was entitled “Do you have the lungs of a footballer?”
Fringe-goers were given the opportunity to undertake an informal testing of their lung health with spirometry and carbon monoxide monitors. We also had a chance to discuss topics including:
lung disease in sport,
and chronic obstructive pulmonary disease (COPD).
Imperial College estimated 700 people attended the event. If you’d like to follow the work of the Muscle lab you can follow us on Twitter @NHLIRespMuscle.
Did you know?
Smoking is the leading cause of death in Great Britain, in 2013 80,000 deaths were attributable to smoking in England. Smoking costs the NHS UK £5.2 billion (2005/06). 19% of adults in Great Britain currently smoke (down from a peak of 46% in 1974), 20% of men and 17% of women currently smoke (www.ons.gov.uk).
Air pollution is a major environmental risk to health. Examples of air pollutants are nitrogen dioxide and particulates. Annually 40,000 deaths are attributable to exposure to outdoor air pollution (www.rcplondon.ac.uk).
We hear from a member of the NHLI Postdoc Committee and a PhD student on their experiences of the NHLI Postdoc Day that was held on January 23rd 2017. The event is designed to give our postdocs an opportunity to explore their career options and focus on their career progression as well as to network with other NHLI postdocs.
NHLI Postdoc Day 2017 from the perspective of the Postdoc Committee
Life as a postdoctoral researcher isn’t always straightforward. Although you’ve completed the seemingly unending task of your PhD, which is a large weight off your shoulders, by taking the next logical step and becoming a postdoctoral researcher, your future can feel uncertain. With only 1/10 postdoctoral researchers successful in pursuing a career in academia, making the best of every opportunity is key. This was clearly highlighted at the NHLI Postdoc Day on 23rd January.
Hearing from successful postdocs in how they have managed to drive their career forward, despite setbacks was both heartening and inspirational, and their ‘hints and tips’ were extremely useful!
The day began with a talk from the PostDoc Development Centre representative Karen Hinxman. Karen highlighted what the PDC could do to help the postdocs at Imperial. From CV checking to running courses and giving mock interviews for prospective job and fellowship applications, the PDC is an invaluable resource. We then heard from three researchers, Dr Louise Blakemore, Dr James Harker and Dr Jon Wilkinson highlighting the different pathways that a postdoctoral researcher wishing to take the academic route can take. Hearing from successful postdocs in how they have managed to drive their career forward, despite setbacks was both heartening and inspirational, and their ‘hints and tips’ were extremely useful! We then heard some enlightening talks about how Athena SWAN initiatives can help our career development and also the importance of open access publishing. Lunch provided the opportunity to network with fellow postdocs and also to meet the postdoc reps and speakers – and ask them any questions.
After lunch we heard from Sarah Lloyd from the Wellcome Trust who gave us an overview of the funding offered to postdocs, both early career and those looking to establish their own research groups, and also gave us some key tips to help with applications. Dr Charlotte Dean, a PI from Imperial, then outlined her career path and how it fit in with family life. The day ended with three former NHLI postdocs and alternative career paths they have taken, in industry, academic publishing and public outreach which was both eye opening and informative, and let us know that life on the bench isn’t the only option post-PhD.
As an early career postdoctoral researcher, I found this whole day invaluable, and the event has helped me to gain some much-needed direction in driving my career forward!
By Sara Bonvini
NHLI Postdoc Day 2017 from the Perspective of a Final Year PhD student
Being a final year PhD student brings lots of questions and uncertainties. Apart from the PhD project itself, the most burning question is – “What next?”. According to The Royal Society (2010), only about 3.5% of PhD students stay in academia/University research, so what happens to the rest of them and what will happen to me?
The rest of the presentations were interesting and inspirational stories of journeys of some of the ex-NHLI postdocs.
The NHLI Postdoc Day, to which they invite PhD students in their final year, can help to answer some of these questions. The day is filled with lectures and this year we had eleven speakers. About half of the presentations were about the support for postdocs that is available at the Imperial College London and NHLI – the Postdoc Development Centre, the Open Access Publishing, the Wellcome Trust Funding, and the Athena SWAN programme. To me as a PhD student, it was useful to learn what it would be like to take a postdoc position at the College or specifically with NHLI.
The rest of the presentations were interesting and inspirational stories of journeys of some of the ex-NHLI postdocs. It was reassuring to hear that the road after PhD is not always a straight one. It can take turns and bumps due to personal or family priorities at a time, but rather that being a hindrance, it can actually enrich and expand our scientific world; being it teaching science to children abroad, or working as a scientist in an industry developing a diagnostic assay for clinical use.
I enjoyed all the presentations, and I learnt a lot. I believe that it would be beneficial to all PhD students, regardless of how far in their PhD they are. It might inspire them and help them to understand the different challenges and possibilities inside and outside of academia after they finish their PhD.